Application of Cyclodextrin in Green Organic Chemistry

Green organic chemistry with environmental protection and sustainable development has two distinct characteristics compared with traditional organic chemistry (1) high atomic economy, making full use of the atoms of the reactants to bind to the target molecule, Reaction yield; (2) mild reaction conditions, catalyst and reaction carrier can be reused, the reaction components are environmentally friendly and can be recycled and regenerated. The most direct manifestation is the green organic synthesis. The cavities of cyclodextrin interact with hydrophobic organic molecules to form reversible host-guest clathrate to increase the solubility of hydrophobic guest molecules in water, allowing organic reactions to be carried out in environmentally friendly water. At the same time, the cavity is rich in electricity, can affect the guest molecules of the electrical environment, so that the reaction can be carried out under mild conditions can be effective. The hydroxyl groups on the cyclodextrin cone can also be carried out in a favorable direction by hydrogen bonding between the host and guest.
In recent years, the application of cyclodextrin in green organic chemistry has become a new research hotspot. Cyclodextrin can be divided into several types of reactions, such as oxidation, addition, ring-opening, deprotection, coupling and substitution. Therefore, cyclodextrin is a kind of excellent performance of the green organic reaction catalyst. With the application of cyclodextrin, the field of cyclodextrin has been extended from the traditional field of simple synthesis, such as substitution and ester hydrolysis, to the field of green and efficient catalysis. It is foreseeable that with the deepening of the research on the mechanism of cyclodextrin catalysis, new green organic reactions will be endless.